Abstract Positron emission tomography PET is becoming more frequently used by medicinal chemists to facilitate the selection of the most promising lead compounds for further evaluation. The advantageous characteristics of the positron emitting isotope 18F, 9 and the prominent position of fluorine substitution in drug discovery 10 have fuelled an upsurge of interest in 18F-radiochemistry, with the appearance of novel methods for 18F-labeling inspired by modern 19F chemistry.
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