There was no significant difference in inducible clindamycin resistance regarding to methicillin susceptibility pattern. The emergence of antibiotic resistance, especially methicillin resistance in Gram positive cocci, considers clindamycin as an acceptable alternative treatment option. Frequency of different patterns of susceptibility to erythromycin and clindamycin in staphylococcus isolates. However regarding wide spread use of this antibiotic, increasing number of resistant isolates are being developed 1 , 7. These antibiotic share common binding sites thus called MLSB phenotype 2. J Clin Diagn Res ; 5: The common mechanism of resistance is via erm gene encoding for enzymes confer constitutive or inducible resistance to MLS B family 7 , 15 —
Phenotypic detection of inducible clindamycin resistance among Staphylococcus aureus isolates by using the lower limit of recommended inter-disk distance. Inducible clindamycin resistance among clinical isolates of staphylococci. Detection of inducible clindamcin resistance of staphylococci in conjuction with performance of automated broth susceptibility testing. Inducible clindamycin resistancein Staphylococci: Open in a separate window.
Jundishapur Journal of Microbiology
Table 2 Association of clindamycin resistance with methicillin resistance. Accurate designation of antimicrobial susceptibility pattern of the infecting microorganisms is an important crucial factor in making appropriate therapeutic decisions 2 There is no substantial data regarding clindamycin prescription from India.
Clinical and Laboratory Standards Institute; There was no significant difference in inducible clindamycin resistance regarding to methicillin susceptibility pattern. Total number of microorganisms from different clinical samples was subjected to the study including In a study by Dibah et al. In recent times, thesiw has become an excellent drug for some Staphylococcal infections, particularly skin and soft tissue infections and as an alternative in penicillin-allergic patients.
All the erythromycin-sensitive strains were excluded.
Inducible Clindamycin Resistance in Staphylococcus aureus Isolated from Clinical Samples
Detection of inducible clindamcin resistance of staphylococci in conjuction with performance of automated broth susceptibility testing. Jpn J Infect Dis. Frequency of inducible clindamycin resistance regarding to different clinical specimens. J Lab Physicians ; 3: Incidence of constitutive and inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci in a community and a tertiary care hospital.
If they indycible resistant to erythromycin and sensitive to clindamycin in primary antibiotic susceptibility testing by Kirby-Bauer method, they were subjected to D-zone testing to detect possible inducible clindamycin resistance. However regarding wide spread use of this antibiotic, clindammycin number of resistant isolates are being developed 17.
High prevalence of inducible clindamycin resistance among Staphylococcus aureus isolates from patients with cystic fibrosis. According to our findings, considerable number of bacterial isolates in our center clidnamycin iMBL pattern.
This article has been cited by other articles in PMC. Clinical and laboratory standards institute. Routine quality control of knducible disks was performed by S. However regarding wide spread use of this antibiotic, increasing number of resistant isolates are being developed 17.
In such cases treatment with clindamycin may lead to clinical failure by developing constitutive resistant microorganisms 159. High prevalence of inducible clindamycin resistance among Staphylococcus aureus isolates from patients with cystic fibrosis.
J Clin Microbiol ; Potential clindamycin resistance in clindamycin-susceptible, erythromycin-resistant Staphylococcus aureus: Iran J Microbiol ; 7: Detection of inducible clindamycin resistance in Staphylococus aureus and coagulase-negative staphylococci- a study from South India. Inducible clindamycin resistancein Staphylococci: Amongst MLSB group, clindamycin has been considered as the preferred agent due to its excellent pharmacokinetic properties 1245 including good penetration and distribution in to the skin and other soft tissue structures 6 and acceptable oral absorption with no dosage adjustment in renal disorders clindamycij.
The increasing prevalence of methicillin resistance among Staphylococci is an increasing problem.
We also determined the frequency of inducible clindamycin resistance in different hospital wards and clindmycin samples. Clin Infect Dis ; In our study the rate of inducible and constitutive clindamycin resistance among erythromycin resistant microorganisms was Methicillin Susceptibility MS Pattern.